USP40
Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin specific peptidase 40 | MIM:610570 | Ensembl:ENSG00000085982 | HGNC:HGNC:20069 | PA134909324 | 2q37.1 |
GO terms in USP40
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IBA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IEA | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0016579 | protein deubiquitination |
| BP | IEA | GO:0016579 | protein deubiquitination |
| BP | IBA | GO:0031647 | regulation of protein stability |
| CC | IBA | GO:0005829 | cytosol |
Gene expression in normal tissue: USP40
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in USP40
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in USP40
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.