ZMYND10
Summary: This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger MYND-type containing 10 | MIM:607070 | Ensembl:ENSG00000004838 | HGNC:HGNC:19412 | PA134981649 | 3p21.31 |
GO terms in ZMYND10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0036158 | outer dynein arm assembly |
| BP | IMP | GO:0036158 | outer dynein arm assembly |
| BP | ISS | GO:0036158 | outer dynein arm assembly |
| BP | IBA | GO:0036159 | inner dynein arm assembly |
| BP | IMP | GO:0036159 | inner dynein arm assembly |
| BP | ISS | GO:0036159 | inner dynein arm assembly |
| BP | IBA | GO:0044458 | motile cilium assembly |
| BP | IMP | GO:0044458 | motile cilium assembly |
| BP | ISS | GO:1905505 | positive regulation of motile cilium assembly |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0034451 | centriolar satellite |
| CC | ISS | GO:0034451 | centriolar satellite |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ZMYND10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMYND10
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZMYND10
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.