iGMDRD1027

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Standard Name
CHEMBL
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTrastuzumab-based therapy
CHEMBLCHEMBL1201585
KEGG Drug IDD03257
DRUGBANK IDDB00072
Drug StatusAlone
Drug TypeBiotech



Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Adenoid Cystic Carcinoma of the Lung (LUACC) model num: 1

Drug-gene pathway enrichments

2reactome: GRB2 events in ERBB2 signaling2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signal Transduction2reactome: SHC1 events in ERBB2 signaling2reactome: Signaling by ERBB21reactome: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors1reactome: Intracellular signaling by second messengers1biocarta: role of erbb2 in signal transduction and oncology1pid: a6b1 and a6b4 Integrin signaling1biocarta: trefoil factors initiate mucosal healing

Drug-gene GO enrichments

4MF: protein tyrosine kinase activity3CC: receptor complex3CC: plasma membrane2BP: transmembrane receptor protein tyrosine kinase signaling pathway2MF: transmembrane receptor protein tyrosine kinase activity2MF: transmembrane signaling receptor activity2MF: protein heterodimerization activity1CC: basal plasma membrane1CC: integral component of membrane1CC: endosome membrane

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 1
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Gene in drug-gene network: Network Plot

Models in Trastuzumab-based therapy

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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