iGMDRD344

Canonical SMILES: CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O

InChI: InChI=1S/C19H18ClF3N2O5S/c1-18(28,19(21,22)23)17(27)24-15-9-8-13(10-14(15)20)31(29,30)12-6-4-11(5-7-12)16(26)25(2)3/h4-10,28H,1-3H3,(H,24,27)

InChI Key: DTDZLJHKVNTQGZ-UHFFFAOYSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameAZD7545
CHEMBLCHEMBL3392645
Pubchem CID9805100
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

PDK2

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 1

Drug-gene pathway enrichments

2reactome: SMAC-mediated apoptotic response2reactome: Apoptotic factor-mediated response2reactome: Apoptosis2reactome: SMAC-mediated dissociation of IAP:caspase complexes2reactome: Programmed Cell Death2reactome: SMAC binds to IAPs2reactome: Intrinsic Pathway for Apoptosis1wikipathways: Pilocytic astrocytoma1wikipathways: Signaling Pathways in Glioblastoma1wikipathways: Aryl Hydrocarbon Receptor

Drug-gene GO enrichments

3BP: positive regulation of GTPase activity2CC: mitochondrion2BP: negative regulation of MAPK cascade2CC: cytosol2BP: MAPK cascade2BP: positive regulation of apoptotic process2MF: protein binding2BP: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c2BP: extrinsic apoptotic signaling pathway via death domain receptors1BP: positive regulation of neuron apoptotic process

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
56616 DIABLO 1
4763 NF1 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in AZD7545

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.