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iGMDRD40

Canonical SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChI Key: BNRNXUUZRGQAQC-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Sildenafil	CHEMBL192	5212	D08514	DB00203	Alone	DAP000614	Small Molecule

Drug Class:

Amides Cardiovascular Agents CYP3A Substrates (Sensitive)Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak)Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Drugs Used in Erectile Dysfunction Enzyme Inhibitors Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Phosphodiesterase 5 Inhibitors Phosphodiesterase Inhibitors Piperazines Purines Sulfonamides Sulfones Sulfur Compounds Urological Agents Urologicals Vasodilating Agents

Drug Targets:

PDE5A (O76074)PDE6G (P18545)PDE6H (Q13956)

Drug Pathways:

cGMP-PKG signaling pathway

Drug Synonyms:

Sildenafil (INN)Aphrodil (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.

Gene in drug-gene network: Network Plot

Models in Sildenafil

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.