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iGMDRD414

Canonical SMILES: C1=CC(=CC(=C1)NC(=O)C2=C(C(=CC=C2)O)O)NC(=O)C3=C(C(=CC=C3)O)O

InChI: InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

InChI Key: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
MST-312	CHEMBL2170856	10385100	Alone	Small Molecule

Drug Targets:

TERT

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	2
7514	XPO1	1
79848	CSPP1	2
7837	PXDN	2
79054	TRPM8	2
7128	TNFAIP3	2
10987	COPS5	7
26191	PTPN22	2
7750	ZMYM2	7
4926	NUMA1	2
11183	MAP4K5	2
29101	SSU72	3
2986	GUCY2F	2
79947	DHDDS	2
57679	ALS2	2
1588	CYP19A1	2
9149	DYRK1B	3
347365	ITIH6	3
1138	CHRNA5	3
23552	CDK20	3
8289	ARID1A	2
80070	ADAMTS20	2
5593	PRKG2	3
4312	MMP1	3
6597	SMARCA4	6
150209	AIFM3	3
9869	SETDB1	3
4036	LRP2	5
5241	PGR	3
843	CASP10	3
3069	HDLBP	3
390502	SERPINA2	3
5079	PAX5	3
10863	ADAM28	2
6598	SMARCB1	1
23213	SULF1	6
5218	CDK14	3
10142	AKAP9	2
7253	TSHR	2
3841	KPNA5	3
57172	CAMK1G	3
22821	RASA3	9
6455	SH3GL1	3
79934	COQ8B	5
54822	TRPM7	3
943	TNFRSF8	3
114783	LMTK3	3
1387	CREBBP	3
10454	TAB1	3
3727	JUND	4
23225	NUP210	3
2313	FLI1	5
10013	HDAC6	3
31	ACACA	3
9699	RIMS2	2
5966	REL	2
9411	ARHGAP29	8
85021	REPS1	2
10438	C1D	5
3456	IFNB1	6
9024	BRSK2	3
5166	PDK4	1
55300	PI4K2B	3
10215	OLIG2	3
4851	NOTCH1	3
5314	PKHD1	1
10295	BCKDK	2
9578	CDC42BPB	1
10746	MAP3K2	5
25865	PRKD2	5
25925	ZNF521	2
54477	PLEKHA5	2
57670	KIAA1549	4
22861	NLRP1	2
837	CASP4	2
440279	UNC13C	2
816	CAMK2B	3
84033	OBSCN	3
5607	MAP2K5	5
11073	TOPBP1	2
2051	EPHB6	2
9693	RAPGEF2	2
57787	MARK4	5
222484	LNX2	3
1586	CYP17A1	8
3091	HIF1A	3
4005	LMO2	3
6041	RNASEL	3
9175	MAP3K13	3
200576	PIKFYVE	2
80351	TNKS2	3
6733	SRPK2	4
6091	ROBO1	6
2042	EPHA3	5
23255	MTCL1	3
9636	ISG15	1
11169	WDHD1	3
1936	EEF1D	3
83990	BRIP1	6
284217	LAMA1	3
269	AMHR2	2
83931	STK40	2
4982	TNFRSF11B	2
2045	EPHA7	2
23405	DICER1	2
1992	SERPINB1	3
399979	SNX19	3
65217	PCDH15	3
286826	LIN9	6
23191	CYFIP1	3
23387	SIK3	5
4294	MAP3K10	3
7525	YES1	3
1973	EIF4A1	3
50488	MINK1	3
2068	ERCC2	3
5591	PRKDC	2
80312	TET1	2
79705	LRRK1	2
5568	PRKACG	5
8091	HMGA2	3
6098	ROS1	3
9472	AKAP6	2
638	BIK	3
3685	ITGAV	3
8945	BTRC	2
1009	CDH11	6
2521	FUS	2
3397	ID1	2
5924	RASGRF2	3
2734	GLG1	3
84433	CARD11	3
6792	CDKL5	2
7010	TEK	6
7533	YWHAH	6
5450	POU2AF1	1
898	CCNE1	8
23152	CIC	2
2066	ERBB4	1
5327	PLAT	3
5863	RGL2	2
10290	SPEG	4
1029	CDKN2A	5
5108	PCM1	6
28514	DLL1	2
6092	ROBO2	4
4602	MYB	2
79058	ASPSCR1	2
6714	SRC	1
6794	STK11	4
57194	ATP10A	4
3791	KDR	4
10114	HIPK3	3
6772	STAT1	3
93210	PGAP3	4
3000	GUCY2D	3
2263	FGFR2	3
8408	ULK1	3
84075	FSCB	2
105	ADARB2	3
344387	CDKL4	3
8874	ARHGEF7	6
1555	CYP2B6	1
51086	TNNI3K	1
5600	MAPK11	2
2309	FOXO3	2
8660	IRS2	3
57188	ADAMTSL3	2
57105	CYSLTR2	2
65125	WNK1	2
136332	LRGUK	3
4436	MSH2	2
6035	RNASE1	3
7175	TPR	3
80205	CHD9	3
4026	LPP	5
8997	KALRN	3
6795	AURKC	9
2071	ERCC3	3
57111	RAB25	1
54658	UGT1A1	1
6654	SOS1	4
7204	TRIO	3
5297	PI4KA	2
10769	PLK2	6
30827	CXXC1	3
5578	PRKCA	1
4214	MAP3K1	9
3702	ITK	3
9972	NUP153	2
3239	HOXD13	3
50615	IL21R	2
5290	PIK3CA	6
3720	JARID2	6
5034	P4HB	6
26524	LATS2	3
253260	RICTOR	3
6391	SDHC	3
5045	FURIN	1
64919	BCL11B	3
2030	SLC29A1	3
675	BRCA2	1
607	BCL9	2
4803	NGF	2
10155	TRIM28	3
7075	TIE1	2
1956	EGFR	3
4609	MYC	3
64333	ARHGAP9	2
11064	CNTRL	3
5789	PTPRD	1
8795	TNFRSF10B	1
4684	NCAM1	3
26278	SACS	7
29951	PDZRN4	5
5663	PSEN1	2
5187	PER1	4
7917	BAG6	2
375056	MIA3	3
137872	ADHFE1	7
3949	LDLR	2
23005	MAPKBP1	4
7153	TOP2A	2
57082	KNL1	1
84630	TTBK1	8
1213	CLTC	3
22976	PAXIP1	2
83452	RAB33B	6
57538	ALPK3	3
5598	MAPK7	1
8924	HERC2	2
339345	NANOS2	6
6095	RORA	3
29844	TFPT	3
7301	TYRO3	1
8029	CUBN	2
9113	LATS1	4
7849	PAX8	3
9321	TRIP11	3
1230	CCR1	5
9509	ADAMTS2	1
10752	CHL1	5
23476	BRD4	3
51330	TNFRSF12A	3
1487	CTBP1	3
140609	NEK7	3
8888	MCM3AP	3
667	DST	3
1974	EIF4A2	3
4004	LMO1	1
140803	TRPM6	3
2324	FLT4	4
85409	NKD2	2
9344	TAOK2	3
23090	ZNF423	3
3899	AFF3	3
7273	TTN	2
1445	CSK	3
79834	PEAK1	2
5582	PRKCG	2
85415	RHPN2	3
23389	MED13L	6
8028	MLLT10	3
6787	NEK4	6
8667	EIF3H	6
54904	NSD3	2
387	RHOA	6
29941	PKN3	4
3161	HMMR	2
2046	EPHA8	2
10243	GPHN	8
8805	TRIM24	6
8394	PIP5K1A	3
344905	ATP13A5	2
51151	SLC45A2	3
3611	ILK	3
7248	TSC1	3
3297	HSF1	3
5562	PRKAA1	3
2690	GHR	1
2317	FLNB	6
8031	NCOA4	3
10111	RAD50	1
6790	AURKA	3
1789	DNMT3B	3
53353	LRP1B	6
7094	TLN1	5
5609	MAP2K7	2
1281	COL3A1	5
9201	DCLK1	2
2185	PTK2B	3
63976	PRDM16	5
5335	PLCG1	2
131890	GRK7	3
2194	FASN	3
598	BCL2L1	2
57448	BIRC6	4
8317	CDC7	2
3717	JAK2	9
7099	TLR4	3
7227	TRPS1	2
53335	BCL11A	3
5506	PPP1R3A	3
79837	PIP4K2C	4
57118	CAMK1D	3
4221	MEN1	3
8428	STK24	3
4772	NFATC1	2
51562	MBIP	1
4261	CIITA	3
4330	MN1	2
182	JAG1	1
7046	TGFBR1	1
80781	COL18A1	4
4974	OMG	5
5925	RB1	5
2065	ERBB3	3
25	ABL1	3
862	RUNX1T1	2
7403	KDM6A	1
1432	MAPK14	9
112268437	LOC112268437	2
4205	MEF2A	3
3716	JAK1	3
3488	IGFBP5	2
3480	IGF1R	2
4915	NTRK2	3
2261	FGFR3	3
23072	HECW1	3
3237	HOXD11	3
5567	PRKACB	4
4040	LRP6	4
55422	ZNF331	4
581	BAX	1
3092	HIP1	2
156	GRK2	3
4763	NF1	3
57697	FANCM	2
1612	DAPK1	4
9625	AATK	3
63893	UBE2O	6
1840	DTX1	2
4591	TRIM37	5
10891	PPARGC1A	3
440270	GOLGA8B	3
2044	EPHA5	5
5287	PIK3C2B	1
3110	MNX1	3
3679	ITGA7	3
6943	TCF21	3
1608	DGKG	2
7294	TXK	2
6868	ADAM17	3
23112	TNRC6B	4
27255	CNTN6	3
1499	CTNNB1	3
2444	FRK	8
3440	IFNA2	12
2892	GRIA3	5
4916	NTRK3	6
1795	DOCK3	3
167359	NIM1K	1
5624	PROC	2
5970	RELA	6
5590	PRKCZ	2

Gene in drug-gene network: Network Plot

Models in MST-312

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.