iGMDRD419

Canonical SMILES: CC1CC(C(OC1CC=C(C)C=CC2C(C3(CC(O2)(C)OC)CO3)O)C)NC(=O)C=CC(C)OC(=O)C

InChI: InChI=1S/C28H43NO8/c1-17(9-12-24-26(32)28(16-34-28)15-27(6,33-7)37-24)8-11-23-18(2)14-22(20(4)36-23)29-25(31)13-10-19(3)35-21(5)30/h8-10,12-13,18-20,22-24,26,32H,11,14-16H2,1-7H3,(H,29,31)/b12-9+,13-10-,17-8+/t18-,19-,20+,22+,23-,24+,26+,27-,28+/m0/s1

InChI Key: XKSGIJNRMWHQIQ-CGPJBNNXSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameSpliceostatin A
Pubchem CID10673600
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2

Drug-gene pathway enrichments

1reactome: mRNA Splicing1reactome: Processing of Capped Intron-Containing Pre-mRNA1reactome: Gene expression (Transcription)1reactome: Metabolism of RNA1reactome: mRNA Splicing - Minor Pathway1reactome: mRNA Splicing - Major Pathway1kegg: Spliceosome - Homo sapiens (human)1reactome: Epigenetic regulation of gene expression1reactome: Positive epigenetic regulation of rRNA expression1reactome: B-WICH complex positively regulates rRNA expression

Drug-gene GO enrichments

4BP: mRNA splicing, via spliceosome2CC: catalytic step 2 spliceosome2CC: U2 snRNP2CC: U12-type spliceosomal complex1BP: RNA splicing, via transesterification reactions1MF: protein binding1MF: mRNA binding1BP: positive regulation of gene expression, epigenetic1MF: RNA binding1BP: spliceosomal complex assembly

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
23451 SF3B1 2
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Gene in drug-gene network: Network Plot

Models in Spliceostatin A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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