iGMDRD578

Canonical SMILES: C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F

InChI: InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

InChI Key: JGWRKYUXBBNENE-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NamePLX3397
CHEMBLCHEMBL3813873
Pubchem CID25151400
DRUGBANK IDDB12978
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

PNtissue: PN cancer: PNS model num: 0PNStissue: PNS cancer: Neurofibroma (NFIB) model num: 4

Drug-gene pathway enrichments

1wikipathways: Ras Signaling1wikipathways: MAPK Signaling Pathway1wikipathways: MECP2 and Associated Rett Syndrome1wikipathways: Aryl Hydrocarbon Receptor1kegg: MAPK signaling pathway - Homo sapiens (human)1kegg: Ras signaling pathway - Homo sapiens (human)1pid: Syndecan-2-mediated signaling events1pid: Regulation of Ras family activation1pid: FOXA2 and FOXA3 transcription factor networks1pid: ATF-2 transcription factor network

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4763 NF1 4
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Gene in drug-gene network: Network Plot

Models in PLX3397

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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