iGMDRD677

Canonical SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

InChI: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

InChI Key: LQBVNQSMGBZMKD-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameABT-199 (GDC-0199)
CHEMBLCHEMBL3137309
Pubchem CID49846600
DRUGBANK IDDB11581
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

BCL2 (P10415)

Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 2BLOODtissue: BLOOD cancer: Multiple Myeloma (MM) model num: 1BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 3

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3418 IDH2 1
2322 FLT3 1
3417 IDH1 1
7301 TYRO3 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in ABT-199 (GDC-0199)

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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