iGMDRD725

Canonical SMILES: CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N

InChI: InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32)

InChI Key: QINPEPAQOBZPOF-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NamePilaralisib
CHEMBLCHEMBL3360203
Pubchem CID56599300
DRUGBANK IDDB11772
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

PIK3CA (P42336)

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Drug-gene pathway enrichments

2reactome: GRB2 events in ERBB2 signaling2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signal Transduction2reactome: SHC1 events in ERBB2 signaling2reactome: Signaling by ERBB21reactome: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors1reactome: Intracellular signaling by second messengers1biocarta: role of erbb2 in signal transduction and oncology1pid: a6b1 and a6b4 Integrin signaling1biocarta: trefoil factors initiate mucosal healing

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 1
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Gene in drug-gene network: Network Plot

Models in Pilaralisib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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