iGMDRD790
Canonical SMILES: CC(C)(CNC1=NC(=NC(=N1)NC2=CC(=NC=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F)O
InChI: InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
InChI Key: DYLUUSLLRIQKOE-UHFFFAOYSA-N
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Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
Standard NameAG-221 CHEMBLCHEMBL3989908 Pubchem CID89683800 DRUGBANK IDDB13874 Drug StatusAlone Drug TypeSmall Molecule | |||||
Drug Class:
AminesBCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingIsocitrate Dehydrogenase 2 InhibitorP-glycoprotein/ABCB1 InhibitorsPyridinesUGT1A1 InhibitorsUGT1A1 SubstratesDrug Targets:
IDH2 (P48735)Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
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Gene ID | Gene Name | Model Num. |
|---|---|---|
| 3418 | IDH2 | 7 |
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Gene in drug-gene network: Network Plot
Models in AG-221
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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