iGMDRD81

Canonical SMILES: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

InChI: InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1

InChI Key: UWKQSNNFCGGAFS-XIFFEERXSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug targets (TTD)
Drug Type
Standard NameIrinotecan plus CHK1/2 inhibitor in ATM deficient tumor
CHEMBLCHEMBL481 CHEMBL541887 CHEMBL1200512
Pubchem CID60838
KEGG Drug IDD01061
DRUGBANK IDDB00762
Drug StatusCombination
Drug targets (TTD)DAP001339
Drug TypeSmall Molecule




Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

2reactome: Cell Cycle1reactome: Cellular responses to external stimuli1reactome: Gene expression (Transcription)1reactome: Meiotic recombination1wikipathways: miRNA Regulation of DNA Damage Response1reactome: DNA Repair1reactome: Cell Cycle Checkpoints1reactome: Regulation of TP53 Activity through Phosphorylation1reactome: G2/M DNA damage checkpoint1reactome: G2/M Checkpoints

Drug-gene GO enrichments

4CC: nuclear chromosome, telomeric region3CC: Mre11 complex2CC: site of double-strand break2MF: single-stranded DNA endodeoxyribonuclease activity2BP: DNA duplex unwinding2BP: nucleic acid phosphodiester bond hydrolysis2MF: ATP-dependent DNA helicase activity2CC: nucleoplasm2BP: telomere maintenance via telomerase2MF: 3'-5' exonuclease activity

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
10111 RAD50 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in Irinotecan plus CHK1/2 inhibitor in ATM deficient tumor

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.