iGMDRD979

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Standard Name
DRUGBANK ID
Drug Status
Drug Type
Standard NamePertuzumab
DRUGBANK IDDB06366
Drug StatusAlone
Drug TypeBiotech

Drug-model tissue-cancer distribution: Bubble Plot

STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophagogastric Carcinoma model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 18BILIARY_TRACtissue: BILIARY_TRAC cancer: BILIARY_TRACT model num: 0BILIARY_TRACTtissue: BILIARY_TRACT cancer: Biliary Cancer model num: 2OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 2PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Cancer model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1

Drug-gene pathway enrichments

4reactome: Signaling by ERBB24reactome: Signaling by Receptor Tyrosine Kinases4reactome: SHC1 events in ERBB2 signaling4reactome: Signal Transduction2reactome: Constitutive Signaling by Aberrant PI3K in Cancer2reactome: Diseases of signal transduction2kegg: MAPK signaling pathway - Homo sapiens (human)2reactome: MAPK family signaling cascades2reactome: MAPK1/MAPK3 signaling2reactome: Negative regulation of the PI3K/AKT network

Drug-gene GO enrichments

7MF: protein tyrosine kinase activity6CC: receptor complex4CC: plasma membrane4MF: protein heterodimerization activity4MF: transmembrane signaling receptor activity3CC: integral component of plasma membrane3BP: transmembrane receptor protein tyrosine kinase signaling pathway3MF: growth factor binding3MF: transmembrane receptor protein tyrosine kinase activity3BP: negative regulation of signal transduction

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 23
2065 ERBB3 4
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in Pertuzumab

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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