GNPDA1


Summary: Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glucosamine-6-phosphate deaminase 1MIM:601798Ensembl:ENSG00000113552HGNC:HGNC:4417PA287965q31.3

GO terms in GNPDA1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004342glucosamine-6-phosphate deaminase activity
MFIMPGO:0004342glucosamine-6-phosphate deaminase activity
MFTASGO:0004342glucosamine-6-phosphate deaminase activity
MFIPIGO:0005515protein binding
BPIEAGO:0005975carbohydrate metabolic process
BPIMPGO:0006043glucosamine catabolic process
BPTASGO:0006043glucosamine catabolic process
BPIEAGO:0006044N-acetylglucosamine metabolic process
BPIBAGO:0006046N-acetylglucosamine catabolic process
BPIBAGO:0006048UDP-N-acetylglucosamine biosynthetic process
BPIMPGO:0006091generation of precursor metabolites and energy
BPTASGO:0007338single fertilization
BPIBAGO:0019262N-acetylneuraminate catabolic process
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: GNPDA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GNPDA1


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-70171Glycolysis
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
kegghsa00520Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
humancycGLUAMCAT-PWYN-acetylglucosamine degradation I
humancycPWY-5514UDP-N-acetyl-D-galactosamine biosynthesis II
humancycPWY-6517N-acetylglucosamine degradation II
smpdbSMP00045Amino Sugar Metabolism
smpdbSMP00216Sialuria or French Type Sialuria
smpdbSMP00217Sialuria or French Type Sialuria
smpdbSMP00240Salla Disease/Infantile Sialic Acid Storage Disease
smpdbSMP00390Tay-Sachs Disease
smpdbSMP00534G(M2)-Gangliosidosis: Variant B, Tay-sachs disease

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GNPDA1

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