GNPDA1
Summary: Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glucosamine-6-phosphate deaminase 1 | MIM:601798 | Ensembl:ENSG00000113552 | HGNC:HGNC:4417 | PA28796 | 5q31.3 |
GO terms in GNPDA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004342 | glucosamine-6-phosphate deaminase activity |
| MF | IMP | GO:0004342 | glucosamine-6-phosphate deaminase activity |
| MF | TAS | GO:0004342 | glucosamine-6-phosphate deaminase activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0005975 | carbohydrate metabolic process |
| BP | IMP | GO:0006043 | glucosamine catabolic process |
| BP | TAS | GO:0006043 | glucosamine catabolic process |
| BP | IEA | GO:0006044 | N-acetylglucosamine metabolic process |
| BP | IBA | GO:0006046 | N-acetylglucosamine catabolic process |
| BP | IBA | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process |
| BP | IMP | GO:0006091 | generation of precursor metabolites and energy |
| BP | TAS | GO:0007338 | single fertilization |
| BP | IBA | GO:0019262 | N-acetylneuraminate catabolic process |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: GNPDA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GNPDA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| kegg | hsa00520 | Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) |
| humancyc | GLUAMCAT-PWY | N-acetylglucosamine degradation I |
| humancyc | PWY-5514 | UDP-N-acetyl-D-galactosamine biosynthesis II |
| humancyc | PWY-6517 | N-acetylglucosamine degradation II |
| smpdb | SMP00045 | Amino Sugar Metabolism |
| smpdb | SMP00216 | Sialuria or French Type Sialuria |
| smpdb | SMP00217 | Sialuria or French Type Sialuria |
| smpdb | SMP00240 | Salla Disease/Infantile Sialic Acid Storage Disease |
| smpdb | SMP00390 | Tay-Sachs Disease |
| smpdb | SMP00534 | G(M2)-Gangliosidosis: Variant B, Tay-sachs disease |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GNPDA1
CLASSFICATION
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