Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].

hyperpolarization activated cyclic nucleotide gated potassium channel 4MIM:605206Ensembl:ENSG00000138622HGNC:HGNC:16882PA39415q24.1

GO terms in HCN4

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005222intracellular cAMP activated cation channel activity
MFIMPGO:0005248voltage-gated sodium channel activity
MFIDAGO:0005249voltage-gated potassium channel activity
MFIMPGO:0005249voltage-gated potassium channel activity
MFIEAGO:0030552cAMP binding
MFIPIGO:0042802identical protein binding
MFIMPGO:0086041voltage-gated potassium channel activity involved in SA node cell action potential depolarization
BPIMPGO:0002027regulation of heart rate
BPIDAGO:0003254regulation of membrane depolarization
BPIDAGO:0006812cation transport
BPTASGO:0006936muscle contraction
BPNASGO:0008015blood circulation
BPIEAGO:0034765regulation of ion transmembrane transport
BPIMPGO:0035725sodium ion transmembrane transport
BPIMPGO:0042391regulation of membrane potential
BPIMPGO:0055117regulation of cardiac muscle contraction
BPIDAGO:0071320cellular response to cAMP
BPIDAGO:0071321cellular response to cGMP
BPIDAGO:0071805potassium ion transmembrane transport
BPIMPGO:0071805potassium ion transmembrane transport
BPICGO:0086012membrane depolarization during cardiac muscle cell action potential
BPIMPGO:0086015SA node cell action potential
BPIMPGO:0086046membrane depolarization during SA node cell action potential
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIDAGO:0098719sodium ion import across plasma membrane
BPIMPGO:0098909regulation of cardiac muscle cell action potential involved in regulation of contraction
BPIDAGO:1990573potassium ion import across plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0031226intrinsic component of plasma membrane
CCIDAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0098855HCN channel complex

Gene expression in normal tissue: HCN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HCN4

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296061HCN channels
reactomeR-HSA-1296071Potassium Channels
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04742Taste transduction - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HCN4