HCN4
Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hyperpolarization activated cyclic nucleotide gated potassium channel 4 | MIM:605206 | Ensembl:ENSG00000138622 | HGNC:HGNC:16882 | PA394 | 15q24.1 |
GO terms in HCN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005222 | intracellular cAMP activated cation channel activity |
| MF | IMP | GO:0005248 | voltage-gated sodium channel activity |
| MF | IDA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IMP | GO:0005249 | voltage-gated potassium channel activity |
| MF | IEA | GO:0030552 | cAMP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IMP | GO:0086041 | voltage-gated potassium channel activity involved in SA node cell action potential depolarization |
| BP | IMP | GO:0002027 | regulation of heart rate |
| BP | IDA | GO:0003254 | regulation of membrane depolarization |
| BP | IDA | GO:0006812 | cation transport |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | NAS | GO:0008015 | blood circulation |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IMP | GO:0035725 | sodium ion transmembrane transport |
| BP | IMP | GO:0042391 | regulation of membrane potential |
| BP | IMP | GO:0055117 | regulation of cardiac muscle contraction |
| BP | IDA | GO:0071320 | cellular response to cAMP |
| BP | IDA | GO:0071321 | cellular response to cGMP |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| BP | IMP | GO:0071805 | potassium ion transmembrane transport |
| BP | IC | GO:0086012 | membrane depolarization during cardiac muscle cell action potential |
| BP | IMP | GO:0086015 | SA node cell action potential |
| BP | IMP | GO:0086046 | membrane depolarization during SA node cell action potential |
| BP | IMP | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | IDA | GO:0098719 | sodium ion import across plasma membrane |
| BP | IMP | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| BP | IDA | GO:1990573 | potassium ion import across plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0031226 | intrinsic component of plasma membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0098855 | HCN channel complex |
Gene expression in normal tissue: HCN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HCN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296061 | HCN channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| wikipathways | WP1992 | TarBasePathway |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HCN4
CLASSFICATION
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