HCN4

Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namehyperpolarization activated cyclic nucleotide gated potassium channel 4
OMIM IDMIM:605206
Ensembl IDEnsembl:ENSG00000138622
HGNC IDHGNC:HGNC:16882
PHARMGKB IDPA394
Map Location15q24.1

GO terms in HCN4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0005222 intracellular cAMP activated cation channel activity
MF IMP GO:0005248 voltage-gated sodium channel activity
MF IDA GO:0005249 voltage-gated potassium channel activity
MF IMP GO:0005249 voltage-gated potassium channel activity
MF IEA GO:0030552 cAMP binding
MF IPI GO:0042802 identical protein binding
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Gene expression in normal tissue: HCN4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1

Pathways in HCN4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296061 HCN channels
reactome R-HSA-1296071 Potassium Channels
wikipathways WP1992 TarBasePathway
smpdb SMP00296 Acebutolol Action Pathway
smpdb SMP00297 Alprenolol Action Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD309 17AAG 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HCN4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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