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CHAF1A

Summary: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
chromatin assembly factor 1 subunit A	MIM:601246	Ensembl:ENSG00000167670	HGNC:HGNC:1910	PA26446	19p13.3

Gene Categories:

DNA REPAIR

GO terms in CHAF1A

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0000790	nuclear chromatin
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0032991	protein-containing complex
CC	IBA	GO:0033186	CAF-1 complex
CC	IDA	GO:0033186	CAF-1 complex
BP	IEA	GO:0006260	DNA replication
BP	IEA	GO:0006281	DNA repair
BP	IBA	GO:0006334	nucleosome assembly
BP	IDA	GO:0006335	DNA replication-dependent nucleosome assembly
BP	IEA	GO:0007049	cell cycle
BP	IDA	GO:0031497	chromatin assembly
MF	TAS	GO:0003682	chromatin binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0042802	identical protein binding
MF	TAS	GO:0051082	unfolded protein binding
MF	IPI	GO:0070087	chromo shadow domain binding

Gene expression in normal tissue: CHAF1A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHAF1A

Database	Pathway ID	Pathway Des.
wikipathways	WP2002	miR-targeted genes in epithelium - TarBase
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2509	Nanoparticle triggered autophagic cell death
biocarta	btg2pathway	btg family proteins and cell cycle regulation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHAF1A

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DATATYPES

CLASSFICATION

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