CDH8


Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cadherin 8MIM:603008Ensembl:ENSG00000150394HGNC:HGNC:1767PA2630416q21

GO terms in CDH8


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000902cell morphogenesis
BPIBAGO:0007043cell-cell junction assembly
BPTASGO:0007155cell adhesion
BPIBAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007275multicellular organism development
BPIEAGO:0009409response to cold
BPIBAGO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
BPIBAGO:0034332adherens junction organization
BPTASGO:0034332adherens junction organization
BPIBAGO:0035249synaptic transmission, glutamatergic
BPIEAGO:0035249synaptic transmission, glutamatergic
BPIBAGO:0044331cell-cell adhesion mediated by cadherin
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005913cell-cell adherens junction
CCIBAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIBAGO:0016342catenin complex
CCIBAGO:0043083synaptic cleft
CCIEAGO:0043083synaptic cleft
CCIBAGO:0043679axon terminus
CCIEAGO:0043679axon terminus
MFIBAGO:0005509calcium ion binding
MFIEAGO:0005509calcium ion binding
MFIBAGO:0008092cytoskeletal protein binding
MFIEAGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0045296cadherin binding

Gene expression in normal tissue: CDH8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDH8


DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDH8

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