GPC6
Summary: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameglypican 6 OMIM IDMIM:604404 Ensembl IDEnsembl:ENSG00000183098 HGNC IDHGNC:HGNC:4454 PHARMGKB IDPA28835 Map Location13q31.3-q32.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in GPC6
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | TAS | GO:0006027 | glycosaminoglycan catabolic process |
| BP | IEA | GO:0009966 | regulation of signal transduction |
| BP | IDA | GO:0016477 | cell migration |
| BP | IEA | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
Gene expression in normal tissue: GPC6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPC6
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3967 | miR-509-3p alteration of YAP1-ECM axis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPC6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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