RASGRP1
Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603962 Ensembl IDEnsembl:ENSG00000172575 HGNC IDHGNC:HGNC:9878 PHARMGKB IDPA34240 Map Location15q14 | |||||
GO terms in RASGRP1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001816 | cytokine production |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | TAS | GO:0007165 | signal transduction |
Gene expression in normal tissue: RASGRP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASGRP1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASGRP1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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