RCAN2
Summary: This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604876 Ensembl IDEnsembl:ENSG00000172348 HGNC IDHGNC:HGNC:3041 PHARMGKB IDPA162400959 Map Location6p12.3 | |||||
Gene Categories:
PROTEIN PHOSPHATASEGO terms in RCAN2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| CC | ND | GO:0005575 | cellular_component |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
Gene expression in normal tissue: RCAN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RCAN2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RCAN2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.