CDK8


Summary: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin dependent kinase 8MIM:603184Ensembl:ENSG00000132964HGNC:HGNC:1779PA2631513q12.13

GO terms in CDK8


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIBAGO:0006468protein phosphorylation
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0007346regulation of mitotic cell cycle
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0016592mediator complex
CCIDAGO:0016592mediator complex
CCIDAGO:0032991protein-containing complex
MFTASGO:0004672protein kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008353RNA polymerase II carboxy-terminal domain kinase activity

Gene expression in normal tissue: CDK8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDK8


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006936Signaling by TGF-beta family members
biocartaefppathwayestrogen responsive protein efp controls cell cycle and breast tumors growth
netpathPathway_HedgehogHedgehog
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A3
iGMDRD42Vorinostat3
iGMDRD60Quinoclamine3
iGMDRD886Compound 1541A3
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib3
iGMDRD506Fedratinib3
iGMDRD781Sirolimus7
iGMDRD420Leucascandrolide A3
iGMDRD772BRD47702
iGMDRD126Tipifarnib3
iGMDRD435BI-25363
iGMDRD511CHEMBL3993793
iGMDRD280CYTOCHALASIN B3
iGMDRD152179324-69-73
iGMDRD351GW843682X2
iGMDRD57Chloropentafluorobenzene3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK8

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