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EFS

Summary: The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
embryonal Fyn-associated substrate	MIM:609906	Ensembl:ENSG00000100842	HGNC:HGNC:16898	PA134887136	14q11.2

GO terms in EFS

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0017124	SH3 domain binding
MF	IPI	GO:0019904	protein domain specific binding
BP	IEA	GO:0007155	cell adhesion
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IBA	GO:0016477	cell migration
BP	TAS	GO:0035556	intracellular signal transduction
BP	IBA	GO:0090527	actin filament reorganization
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005737	cytoplasm
CC	IBA	GO:0005886	plasma membrane

Gene expression in normal tissue: EFS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EFS

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EFS

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CLASSFICATION

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