SIRPB1


Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
signal regulatory protein beta 1MIM:603889Ensembl:ENSG00000101307HGNC:HGNC:15928PA3805120p13

Gene Categories:

DRUGGABLE GENOME

GO terms in SIRPB1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIBAGO:0022409positive regulation of cell-cell adhesion
BPTASGO:0043312neutrophil degranulation
BPTASGO:0045087innate immune response
BPIBAGO:0050766positive regulation of phagocytosis
BPIBAGO:0050870positive regulation of T cell activation
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0030667secretory granule membrane
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SIRPB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIRPB1


DatabasePathway IDPathway Des.
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-391160Signal regulatory protein family interactions
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIRPB1

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