SIRPB1
Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal regulatory protein beta 1 | MIM:603889 | Ensembl:ENSG00000101307 | HGNC:HGNC:15928 | PA38051 | 20p13 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SIRPB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0022409 | positive regulation of cell-cell adhesion |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IBA | GO:0050766 | positive regulation of phagocytosis |
| BP | IBA | GO:0050870 | positive regulation of T cell activation |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SIRPB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIRPB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIRPB1
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