B3GNT3
Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605863 Ensembl IDEnsembl:ENSG00000179913 HGNC IDHGNC:HGNC:13528 PHARMGKB IDPA25219 Map Location19p13.11 | |||||
GO terms in B3GNT3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0008375 | acetylglucosaminyltransferase activity |
| MF | IBA | GO:0008376 | acetylgalactosaminyltransferase activity |
| MF | TAS | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
| MF | IBA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
| MF | IDA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
| MF | TAS | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
Gene expression in normal tissue: B3GNT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in B3GNT3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638074 | Keratan sulfate/keratin metabolism |
| reactome | R-HSA-2022854 | Keratan sulfate biosynthesis |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5173105 | O-linked glycosylation |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in B3GNT3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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