B3GNT3
Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | MIM:605863 | Ensembl:ENSG00000179913 | HGNC:HGNC:13528 | PA25219 | 19p13.11 |
GO terms in B3GNT3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0008375 | acetylglucosaminyltransferase activity |
MF | IBA | GO:0008376 | acetylgalactosaminyltransferase activity |
MF | TAS | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
MF | IBA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
MF | IDA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
MF | TAS | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
MF | IBA | GO:0016758 | transferase activity, transferring hexosyl groups |
MF | IEA | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity |
BP | IBA | GO:0006486 | protein glycosylation |
BP | IBA | GO:0006493 | protein O-linked glycosylation |
BP | TAS | GO:0016266 | O-glycan processing |
BP | TAS | GO:0018146 | keratan sulfate biosynthetic process |
BP | IBA | GO:0030311 | poly-N-acetyllactosamine biosynthetic process |
BP | IDA | GO:0030311 | poly-N-acetyllactosamine biosynthetic process |
CC | TAS | GO:0000139 | Golgi membrane |
CC | IBA | GO:0005783 | endoplasmic reticulum |
CC | IBA | GO:0005794 | Golgi apparatus |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | IBA | GO:0016020 | membrane |
Gene expression in normal tissue: B3GNT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in B3GNT3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
reactome | R-HSA-1638074 | Keratan sulfate/keratin metabolism |
reactome | R-HSA-2022854 | Keratan sulfate biosynthesis |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-5173105 | O-linked glycosylation |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-71387 | Metabolism of carbohydrates |
reactome | R-HSA-913709 | O-linked glycosylation of mucins |
kegg | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) |
humancyc | PWY-7433 | mucin core 1 and core 2 O-glycosylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in B3GNT3