MYL12B
Summary: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin light chain 12B | MIM:609211 | Ensembl:ENSG00000118680 | HGNC:HGNC:29827 | PA164723274 | 18p11.31 |
GO terms in MYL12B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0032036 | myosin heavy chain binding |
| CC | IEA | GO:0001725 | stress fiber |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005903 | brush border |
| CC | IEA | GO:0016460 | myosin II complex |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0045177 | apical part of cell |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0099738 | cell cortex region |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | IEA | GO:0008360 | regulation of cell shape |
Gene expression in normal tissue: MYL12B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYL12B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYL12B
CLASSFICATION
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