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MYCNOS

Summary: This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameMYCN opposite strand OMIM IDMIM:605374 Ensembl IDEnsembl:ENSG00000233718 HGNC IDHGNC:HGNC:16911 PHARMGKB IDPA134938338 Map Location2p24.3

Gene Categories:

KINASE

GO terms in MYCNOS

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
BP	TAS	GO:0007275	multicellular organism development
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0031647	regulation of protein stability
BP	IDA	GO:0033673	negative regulation of kinase activity
BP	IMP	GO:0043066	negative regulation of apoptotic process

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Gene expression in normal tissue: MYCNOS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYCNOS

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYCNOS

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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