MYCNOS
Summary: This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MYCN opposite strand | MIM:605374 | Ensembl:ENSG00000233718 | HGNC:HGNC:16911 | PA134938338 | 2p24.3 |
Gene Categories:
KINASEGO terms in MYCNOS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IDA | GO:0033673 | negative regulation of kinase activity |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: MYCNOS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYCNOS
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYCNOS
CLASSFICATION
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