YAP1
Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Yes associated protein 1 | MIM:606608 | Ensembl:ENSG00000137693 | HGNC:HGNC:16262 | PA38103 | 11q22.1 |
GO terms in YAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0070064 | proline-rich region binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0071148 | TEAD-1-YAP complex |
| CC | IDA | GO:0071149 | TEAD-2-YAP complex |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0001894 | tissue homeostasis |
| BP | IEA | GO:0003015 | heart process |
| BP | IEA | GO:0003143 | embryonic heart tube morphogenesis |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0010837 | regulation of keratinocyte proliferation |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | IEA | GO:0030857 | negative regulation of epithelial cell differentiation |
| BP | IEA | GO:0030903 | notochord development |
| BP | IDA | GO:0032570 | response to progesterone |
| BP | IDA | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway |
| BP | IEA | GO:0035019 | somatic stem cell population maintenance |
| BP | TAS | GO:0035329 | hippo signaling |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048339 | paraxial mesoderm development |
| BP | IEA | GO:0048368 | lateral mesoderm development |
| BP | IDA | GO:0050767 | regulation of neurogenesis |
| BP | IDA | GO:0050847 | progesterone receptor signaling pathway |
| BP | IEA | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | IDA | GO:0060242 | contact inhibition |
| BP | IEA | GO:0060449 | bud elongation involved in lung branching |
| BP | IEA | GO:0060487 | lung epithelial cell differentiation |
| BP | IEA | GO:0061026 | cardiac muscle tissue regeneration |
| BP | IDA | GO:0065003 | protein-containing complex assembly |
| BP | IMP | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| BP | IDA | GO:0072091 | regulation of stem cell proliferation |
| BP | IEA | GO:0072307 | regulation of metanephric nephron tubule epithelial cell differentiation |
| BP | IEA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| BP | IEA | GO:1902459 | positive regulation of stem cell population maintenance |
| BP | IEA | GO:1903507 | negative regulation of nucleic acid-templated transcription |
| BP | IEA | GO:2000737 | negative regulation of stem cell differentiation |
| BP | IEA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
Gene expression in normal tissue: YAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in YAP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3967 | miR-509-3p alteration of YAP1-ECM axis |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | p73pathway | p73 transcription factor network |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2028269 | Signaling by Hippo |
| reactome | R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD508 | KU0063794 | 1 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD240 | Vandetanib | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD112 | Methotrexate | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in YAP1
CLASSFICATION
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