YAP1


Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Yes associated protein 1MIM:606608Ensembl:ENSG00000137693HGNC:HGNC:16262PA3810311q22.1

GO terms in YAP1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIEAGO:0003682chromatin binding
MFIDAGO:0003713transcription coactivator activity
MFIMPGO:0003713transcription coactivator activity
MFIDAGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIPIGO:0033613activating transcription factor binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIPIGO:0046982protein heterodimerization activity
MFIEAGO:0070064proline-rich region binding
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0016020membrane
CCIDAGO:0071148TEAD-1-YAP complex
CCIDAGO:0071149TEAD-2-YAP complex
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001570vasculogenesis
BPIEAGO:0001894tissue homeostasis
BPIEAGO:0003015heart process
BPIEAGO:0003143embryonic heart tube morphogenesis
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0008283cell proliferation
BPIEAGO:0010837regulation of keratinocyte proliferation
BPIEAGO:0030216keratinocyte differentiation
BPIEAGO:0030857negative regulation of epithelial cell differentiation
BPIEAGO:0030903notochord development
BPIDAGO:0032570response to progesterone
BPIDAGO:0033148positive regulation of intracellular estrogen receptor signaling pathway
BPIEAGO:0035019somatic stem cell population maintenance
BPTASGO:0035329hippo signaling
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048339paraxial mesoderm development
BPIEAGO:0048368lateral mesoderm development
BPIDAGO:0050767regulation of neurogenesis
BPIDAGO:0050847progesterone receptor signaling pathway
BPIEAGO:0060045positive regulation of cardiac muscle cell proliferation
BPIDAGO:0060242contact inhibition
BPIEAGO:0060449bud elongation involved in lung branching
BPIEAGO:0060487lung epithelial cell differentiation
BPIEAGO:0061026cardiac muscle tissue regeneration
BPIDAGO:0065003protein-containing complex assembly
BPIMPGO:0065003protein-containing complex assembly
BPIEAGO:0071300cellular response to retinoic acid
BPIDAGO:0071480cellular response to gamma radiation
BPIDAGO:0072091regulation of stem cell proliferation
BPIEAGO:0072307regulation of metanephric nephron tubule epithelial cell differentiation
BPIEAGO:0090263positive regulation of canonical Wnt signaling pathway
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
BPIEAGO:1902459positive regulation of stem cell population maintenance
BPIEAGO:1903507negative regulation of nucleic acid-templated transcription
BPIEAGO:2000737negative regulation of stem cell differentiation
BPIEAGO:2001237negative regulation of extrinsic apoptotic signaling pathway

Gene expression in normal tissue: YAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YAP1


DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3967miR-509-3p alteration of YAP1-ECM axis
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
piderbb4_pathwayErbB4 signaling events
pidp73pathwayp73 transcription factor network
pidtgfbrpathwayTGF-beta receptor signaling
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1251985Nuclear signaling by ERBB4
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2028269Signaling by Hippo
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-8951671RUNX3 regulates YAP1-mediated transcription
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD42Vorinostat1
iGMDRD421AZD77621
iGMDRD246NPC263
iGMDRD561ABT-2631
iGMDRD329Merck603
iGMDRD508KU00637941
iGMDRD286Nsc 6328396
iGMDRD396AS6012451
iGMDRD105Triptolide3
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin6
iGMDRD251ML1626
iGMDRD883CIL55A4
iGMDRD945ML2146
iGMDRD240Vandetanib1
iGMDRD123Isoevodiamine3
iGMDRD698Neratinib3
iGMDRD594AZD-80551
iGMDRD560MK-22061
iGMDRD324CI-10401
iGMDRD451Serdemetan2
iGMDRD60Quinoclamine3
iGMDRD131Erlotinib1
iGMDRD64Parbendazole6
iGMDRD146Elesclomol1
iGMDRD577BIX012949
iGMDRD506Fedratinib3
iGMDRD399Selumetinib1
iGMDRD100Zebularine2
iGMDRD188Piperlongumine9
iGMDRD187BRD98761
iGMDRD117Docetaxel1
iGMDRD33Entinostat1
iGMDRD260FQI-23
iGMDRD138PX 126
iGMDRD513BML-2591
iGMDRD394BX-7951
iGMDRD401Afatinib1
iGMDRD193Fqi16
iGMDRD608Refametinib1
iGMDRD519GDC-09411
iGMDRD446LY 21832406
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD144NSC953979
iGMDRD546BMS-7548071
iGMDRD313Axitinib1
iGMDRD112Methotrexate1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YAP1

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