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YAP1

Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameYes associated protein 1 OMIM IDMIM:606608 Ensembl IDEnsembl:ENSG00000137693 HGNC IDHGNC:HGNC:16262 PHARMGKB IDPA38103 Map Location11q22.1

Gene Categories:

CLINICALLY ACTIONABLE TRANSCRIPTION FACTOR BINDING TRANSCRIPTION FACTOR COMPLEX

GO terms in YAP1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
MF	IEA	GO:0003682	chromatin binding
MF	IDA	GO:0003713	transcription coactivator activity
MF	IMP	GO:0003713	transcription coactivator activity
MF	IDA	GO:0003714	transcription corepressor activity

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Gene expression in normal tissue: YAP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YAP1

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Database	Pathway ID	Pathway Des.
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3967	miR-509-3p alteration of YAP1-ECM axis
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04392	Hippo signaling pathway - multiple species - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD42	Vorinostat	1
iGMDRD421	AZD7762	1
iGMDRD246	NPC26	3
iGMDRD561	ABT-263	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YAP1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.