GPNMB
Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameglycoprotein nmb OMIM IDMIM:604368 Ensembl IDEnsembl:ENSG00000136235 HGNC IDHGNC:HGNC:4462 PHARMGKB IDPA28845 Map Location7p15.3 | |||||
GO terms in GPNMB
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008201 | heparin binding |
| MF | NAS | GO:0042056 | chemoattractant activity |
| MF | IPI | GO:0045545 | syndecan binding |
| MF | IMP | GO:0048018 | receptor ligand activity |
Gene expression in normal tissue: GPNMB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPNMB
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPNMB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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