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BAIAP2

Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
BAI1 associated protein 2	MIM:605475	Ensembl:ENSG00000175866	HGNC:HGNC:947	PA25251	17q25.3

Gene Categories:

TRANSCRIPTION FACTOR BINDING

GO terms in BAIAP2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0007009	plasma membrane organization
BP	TAS	GO:0007409	axonogenesis
BP	IEA	GO:0007420	brain development
BP	TAS	GO:0008286	insulin receptor signaling pathway
BP	ISS	GO:0008360	regulation of cell shape
BP	IMP	GO:0009617	response to bacterium
BP	IEA	GO:0016358	dendrite development
BP	IBA	GO:0030838	positive regulation of actin filament polymerization
BP	IMP	GO:0032956	regulation of actin cytoskeleton organization
BP	IEA	GO:0035418	protein localization to synapse
BP	TAS	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
BP	TAS	GO:0048010	vascular endothelial growth factor receptor signaling pathway
BP	IEA	GO:0048167	regulation of synaptic plasticity
BP	IBA	GO:0051017	actin filament bundle assembly
BP	ISS	GO:0051017	actin filament bundle assembly
BP	IBA	GO:0051764	actin crosslink formation
BP	ISS	GO:0051764	actin crosslink formation
BP	IEA	GO:0061003	positive regulation of dendritic spine morphogenesis
BP	IEA	GO:0071364	cellular response to epidermal growth factor stimulus
BP	IEA	GO:0098609	cell-cell adhesion
BP	IEA	GO:1905232	cellular response to L-glutamate
BP	IBA	GO:2000251	positive regulation of actin cytoskeleton reorganization
BP	IEA	GO:2000463	positive regulation of excitatory postsynaptic potential
CC	IEA	GO:0001726	ruffle
CC	IBA	GO:0005654	nucleoplasm
CC	TAS	GO:0005737	cytoplasm
CC	IEA	GO:0005791	rough endoplasmic reticulum
CC	IEA	GO:0005794	Golgi apparatus
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005874	microtubule
CC	IDA	GO:0005886	plasma membrane
CC	HDA	GO:0005913	cell-cell adherens junction
CC	IEA	GO:0014069	postsynaptic density
CC	IBA	GO:0015629	actin cytoskeleton
CC	IDA	GO:0015629	actin cytoskeleton
CC	IEA	GO:0030141	secretory granule
CC	IEA	GO:0030175	filopodium
CC	IEA	GO:0043025	neuronal cell body
CC	IEA	GO:0043198	dendritic shaft
CC	IEA	GO:0044306	neuron projection terminus
CC	IEA	GO:0060076	excitatory synapse
CC	IEA	GO:0061845	neuron projection branch point
CC	IEA	GO:0061846	dendritic spine cytoplasm
CC	HDA	GO:0070062	extracellular exosome
CC	IEA	GO:0097060	synaptic membrane
CC	IEA	GO:0098793	presynapse
MF	IEA	GO:0001221	transcription cofactor binding
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0008022	protein C-terminus binding
MF	IEA	GO:0008093	cytoskeletal adaptor activity
MF	IEA	GO:0030165	PDZ domain binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0070064	proline-rich region binding
MF	IEA	GO:0097110	scaffold protein binding
MF	HDA	GO:0098641	cadherin binding involved in cell-cell adhesion

Gene expression in normal tissue: BAIAP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAIAP2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation
reactome	R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs
reactome	R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP51	Regulation of Actin Cytoskeleton
netpath	Pathway_EGFR1	EGFR1
pid	cdc42_pathway	CDC42 signaling events
pid	erbb1_downstream_pathway	ErbB1 downstream signaling
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	rac1_pathway	RAC1 signaling pathway
kegg	hsa04520	Adherens junction - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAIAP2

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DATATYPES

CLASSFICATION

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