SEMA4D
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| semaphorin 4D | MIM:601866 | Ensembl:ENSG00000187764 | HGNC:HGNC:10732 | PA35654 | 9q22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SEMA4D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0030215 | semaphorin receptor binding |
| MF | IPI | GO:0030215 | semaphorin receptor binding |
| MF | ISS | GO:0030215 | semaphorin receptor binding |
| MF | IDA | GO:0038023 | signaling receptor activity |
| MF | IBA | GO:0038191 | neuropilin binding |
| MF | IBA | GO:0045499 | chemorepellent activity |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0001755 | neural crest cell migration |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007162 | negative regulation of cell adhesion |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0010693 | negative regulation of alkaline phosphatase activity |
| BP | IMP | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0031344 | regulation of cell projection organization |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0043931 | ossification involved in bone maturation |
| BP | ISS | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IMP | GO:0048672 | positive regulation of collateral sprouting |
| BP | IMP | GO:0048814 | regulation of dendrite morphogenesis |
| BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
| BP | ISS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0050919 | negative chemotaxis |
| BP | IMP | GO:0070486 | leukocyte aggregation |
| BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
| BP | IDA | GO:0071526 | semaphorin-plexin signaling pathway |
| BP | IMP | GO:0071526 | semaphorin-plexin signaling pathway |
| BP | ISS | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis |
| CC | IBA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: SEMA4D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA4D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-416700 | Other semaphorin interactions |
| reactome | R-HSA-422475 | Axon guidance |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA4D
CLASSFICATION
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