CIB1
Summary: This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium and integrin binding 1 | MIM:602293 | Ensembl:ENSG00000185043 | HGNC:HGNC:16920 | PA38423 | 15q26.1 |
GO terms in CIB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IMP | GO:0008427 | calcium-dependent protein kinase inhibitor activity |
| MF | IPI | GO:0017016 | Ras GTPase binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| MF | IGI | GO:0043495 | protein membrane anchor |
| MF | IEA | GO:0044325 | ion channel binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001933 | negative regulation of protein phosphorylation |
| BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | ISS | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | ISS | GO:0002931 | response to ischemia |
| BP | TAS | GO:0006302 | double-strand break repair |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IDA | GO:0007113 | endomitotic cell cycle |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | ISS | GO:0007286 | spermatid development |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0010977 | negative regulation of neuron projection development |
| BP | ISS | GO:0030220 | platelet formation |
| BP | ISS | GO:0030307 | positive regulation of cell growth |
| BP | ISS | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0031122 | cytoplasmic microtubule organization |
| BP | IDA | GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| BP | ISS | GO:0038163 | thrombopoietin-mediated signaling pathway |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043085 | positive regulation of catalytic activity |
| BP | ISS | GO:0045653 | negative regulation of megakaryocyte differentiation |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0051302 | regulation of cell division |
| BP | ISS | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| BP | IMP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | ISS | GO:0071363 | cellular response to growth factor stimulus |
| BP | IEA | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| BP | ISS | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | ISS | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | IMP | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | TAS | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IDA | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IGI | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IDA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | ISS | GO:2000256 | positive regulation of male germ cell proliferation |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IMP | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0030426 | growth cone |
| CC | HDA | GO:0031982 | vesicle |
| CC | IDA | GO:0032433 | filopodium tip |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0042383 | sarcolemma |
| CC | IDA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071944 | cell periphery |
Gene expression in normal tissue: CIB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CIB1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CIB1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.