CIB1


Summary: This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium and integrin binding 1MIM:602293Ensembl:ENSG00000185043HGNC:HGNC:16920PA3842315q26.1

GO terms in CIB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIMPGO:0008427calcium-dependent protein kinase inhibitor activity
MFIPIGO:0017016Ras GTPase binding
MFIEAGO:0019901protein kinase binding
MFIDAGO:0030291protein serine/threonine kinase inhibitor activity
MFIGIGO:0043495protein membrane anchor
MFIEAGO:0044325ion channel binding
BPIEAGO:0001525angiogenesis
BPISSGO:0001933negative regulation of protein phosphorylation
BPISSGO:0001934positive regulation of protein phosphorylation
BPISSGO:0001954positive regulation of cell-matrix adhesion
BPISSGO:0002931response to ischemia
BPTASGO:0006302double-strand break repair
BPIMPGO:0006915apoptotic process
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0007026negative regulation of microtubule depolymerization
BPIDAGO:0007113endomitotic cell cycle
BPIEAGO:0007155cell adhesion
BPISSGO:0007286spermatid development
BPISSGO:0008284positive regulation of cell proliferation
BPIMPGO:0008285negative regulation of cell proliferation
BPIDAGO:0010977negative regulation of neuron projection development
BPISSGO:0030220platelet formation
BPISSGO:0030307positive regulation of cell growth
BPISSGO:0030335positive regulation of cell migration
BPIMPGO:0031122cytoplasmic microtubule organization
BPIDAGO:0033630positive regulation of cell adhesion mediated by integrin
BPISSGO:0038163thrombopoietin-mediated signaling pathway
BPIMPGO:0042127regulation of cell proliferation
BPIMPGO:0043066negative regulation of apoptotic process
BPISSGO:0043085positive regulation of catalytic activity
BPISSGO:0045653negative regulation of megakaryocyte differentiation
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051301cell division
BPIMPGO:0051302regulation of cell division
BPISSGO:0051898negative regulation of protein kinase B signaling
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070886positive regulation of calcineurin-NFAT signaling cascade
BPIMPGO:0071356cellular response to tumor necrosis factor
BPISSGO:0071363cellular response to growth factor stimulus
BPIEAGO:0071901negative regulation of protein serine/threonine kinase activity
BPISSGO:0071902positive regulation of protein serine/threonine kinase activity
BPISSGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIMPGO:0090314positive regulation of protein targeting to membrane
BPTASGO:0097191extrinsic apoptotic signaling pathway
BPIDAGO:1900026positive regulation of substrate adhesion-dependent cell spreading
BPIGIGO:1903078positive regulation of protein localization to plasma membrane
BPIDAGO:1990090cellular response to nerve growth factor stimulus
BPISSGO:2000256positive regulation of male germ cell proliferation
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIMPGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIMPGO:0005737cytoplasm
CCIMPGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCIDAGO:0005813centrosome
CCIDAGO:0005886plasma membrane
CCIDAGO:0016020membrane
CCIEAGO:0016324apical plasma membrane
CCIDAGO:0030027lamellipodium
CCIEAGO:0030425dendrite
CCIDAGO:0030426growth cone
CCHDAGO:0031982vesicle
CCIDAGO:0032433filopodium tip
CCIEAGO:0032587ruffle membrane
CCIDAGO:0042383sarcolemma
CCIDAGO:0043005neuron projection
CCIDAGO:0043025neuronal cell body
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIDAGO:0071944cell periphery

Gene expression in normal tissue: CIB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CIB1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CIB1

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