ATG7
Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608760 Ensembl IDEnsembl:ENSG00000197548 HGNC IDHGNC:HGNC:16935 PHARMGKB IDPA134983397 Map Location3p25.3 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in ATG7
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004839 | ubiquitin activating enzyme activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0019778 | Atg12 activating enzyme activity |
| MF | ISS | GO:0019778 | Atg12 activating enzyme activity |
| MF | IBA | GO:0019779 | Atg8 activating enzyme activity |
Gene expression in normal tissue: ATG7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATG7
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| reactome | R-HSA-1280218 | Adaptive Immune System |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATG7
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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