GLRX3
Summary: This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutaredoxin 3 | MIM:612754 | Ensembl:ENSG00000108010 | HGNC:HGNC:15987 | PA162389829 | 10q26.3 |
GO terms in GLRX3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002026 | regulation of the force of heart contraction |
| BP | ISS | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| BP | IEA | GO:0022900 | electron transport chain |
| BP | IDA | GO:0044571 | [2Fe-2S] cluster assembly |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IDA | GO:0097428 | protein maturation by iron-sulfur cluster transfer |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0030425 | dendrite |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0009055 | electron transfer activity |
| MF | IEA | GO:0015035 | protein disulfide oxidoreductase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051536 | iron-sulfur cluster binding |
Gene expression in normal tissue: GLRX3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GLRX3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-917937 | Iron uptake and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GLRX3
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