PROCR
Summary: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein C receptor | MIM:600646 | Ensembl:ENSG00000101000 | HGNC:HGNC:9452 | PA33800 | 20q11.22 |
GO terms in PROCR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005813 | centrosome |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0009986 | cell surface |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IMP | GO:0050819 | negative regulation of coagulation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: PROCR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PROCR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-140875 | Common Pathway of Fibrin Clot Formation |
| reactome | R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| biocarta | dbpbpathway | transcriptional activation of dbpb from mrna |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PROCR
CLASSFICATION
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