ARFGEF2

Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameADP ribosylation factor guanine nucleotide exchange factor 2
OMIM IDMIM:605371
Ensembl IDEnsembl:ENSG00000124198
HGNC IDHGNC:HGNC:15853
PHARMGKB IDPA24945
Map Location20q13.13

GO terms in ARFGEF2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0005085 guanyl-nucleotide exchange factor activity
MF IBA GO:0005086 ARF guanyl-nucleotide exchange factor activity
MF IDA GO:0005086 ARF guanyl-nucleotide exchange factor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0017022 myosin binding
MF IDA GO:0034237 protein kinase A regulatory subunit binding
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Gene expression in normal tissue: ARFGEF2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Gene-drug pathway distribution

Mitosis1undefined1Metabolic pathways1

Pathways in ARFGEF2


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Database
Pathway ID
Pathway Des.
kegg hsa04144 Endocytosis - Homo sapiens (human)
reactome R-HSA-390466 Chaperonin-mediated protein folding
reactome R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
reactome R-HSA-391251 Protein folding
reactome R-HSA-392499 Metabolism of proteins
biocarta arappathway adp-ribosylation factor
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 2
iGMDRD992 QL-VIII-58 1
iGMDRD378 ZM-447439 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARFGEF2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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