ARFGEF2
Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADP ribosylation factor guanine nucleotide exchange factor 2 | MIM:605371 | Ensembl:ENSG00000124198 | HGNC:HGNC:15853 | PA24945 | 20q13.13 |
GO terms in ARFGEF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005086 | ARF guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005086 | ARF guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017022 | myosin binding |
| MF | IDA | GO:0034237 | protein kinase A regulatory subunit binding |
| MF | ISS | GO:0050811 | GABA receptor binding |
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | ISS | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005879 | axonemal microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0031410 | cytoplasmic vesicle |
| CC | ISS | GO:0032279 | asymmetric synapse |
| CC | ISS | GO:0032280 | symmetric synapse |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0055037 | recycling endosome |
| BP | IDA | GO:0001881 | receptor recycling |
| BP | IEA | GO:0006887 | exocytosis |
| BP | IMP | GO:0006893 | Golgi to plasma membrane transport |
| BP | IMP | GO:0007032 | endosome organization |
| BP | IMP | GO:0010256 | endomembrane system organization |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0016192 | vesicle-mediated transport |
| BP | IEA | GO:0032012 | regulation of ARF protein signal transduction |
| BP | IMP | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IDA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: ARFGEF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARFGEF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| biocarta | arappathway | adp-ribosylation factor |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD992 | QL-VIII-58 | 1 |
| iGMDRD378 | ZM-447439 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARFGEF2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.