SLC34A2
Summary: The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604217 Ensembl IDEnsembl:ENSG00000157765 HGNC IDHGNC:HGNC:11020 PHARMGKB IDPA35888 Map Location4p15.2 | |||||
GO terms in SLC34A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005436 | sodium:phosphate symporter activity |
| MF | IDA | GO:0005436 | sodium:phosphate symporter activity |
| MF | IBA | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | IDA | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | TAS | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | IDA | GO:0031402 | sodium ion binding |
Gene expression in normal tissue: SLC34A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC34A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC34A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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