SLC34A2
Summary: The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 34 member 2 | MIM:604217 | Ensembl:ENSG00000157765 | HGNC:HGNC:11020 | PA35888 | 4p15.2 |
GO terms in SLC34A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005436 | sodium:phosphate symporter activity |
| MF | IDA | GO:0005436 | sodium:phosphate symporter activity |
| MF | IBA | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | IDA | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | TAS | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | IDA | GO:0031402 | sodium ion binding |
| MF | IDA | GO:0042301 | phosphate ion binding |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IDA | GO:0006817 | phosphate ion transport |
| BP | IBA | GO:0030643 | cellular phosphate ion homeostasis |
| BP | IDA | GO:0030643 | cellular phosphate ion homeostasis |
| BP | IEA | GO:0035725 | sodium ion transmembrane transport |
| BP | IEP | GO:0043627 | response to estrogen |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IBA | GO:0044341 | sodium-dependent phosphate transport |
| BP | IEA | GO:0044341 | sodium-dependent phosphate transport |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005903 | brush border |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0031526 | brush border membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | IBA | GO:0031982 | vesicle |
Gene expression in normal tissue: SLC34A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC34A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-427589 | Type II Na+/Pi cotransporters |
| reactome | R-HSA-427652 | Sodium-coupled phosphate cotransporters |
| reactome | R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) |
| reactome | R-HSA-5619102 | SLC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-5683826 | Surfactant metabolism |
| reactome | R-HSA-5687583 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) |
| reactome | R-HSA-5687613 | Diseases associated with surfactant metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC34A2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.