SORBS1


Summary: This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sorbin and SH3 domain containing 1MIM:605264Ensembl:ENSG00000095637HGNC:HGNC:14565PA3789910q24.1

GO terms in SORBS1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003779actin binding
MFICGO:0005070SH3/SH2 adaptor activity
MFISSGO:0005070SH3/SH2 adaptor activity
MFIDAGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0008092cytoskeletal protein binding
BPTASGO:0006936muscle contraction
BPTASGO:0007160cell-matrix adhesion
BPISSGO:0008286insulin receptor signaling pathway
BPIEAGO:0009967positive regulation of signal transduction
BPISSGO:0032869cellular response to insulin stimulus
BPISSGO:0043149stress fiber assembly
BPISSGO:0045725positive regulation of glycogen biosynthetic process
BPISSGO:0046326positive regulation of glucose import
BPISSGO:0046889positive regulation of lipid biosynthetic process
BPISSGO:0048041focal adhesion assembly
BPISSGO:1903078positive regulation of protein localization to plasma membrane
BPISSGO:2001275positive regulation of glucose import in response to insulin stimulus
CCISSGO:0001725stress fiber
CCIDAGO:0005634nucleus
CCIDAGO:0005813centrosome
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0005899insulin receptor complex
CCISSGO:0005913cell-cell adherens junction
CCTASGO:0005915zonula adherens
CCISSGO:0005924cell-substrate adherens junction
CCIDAGO:0005925focal adhesion
CCIEAGO:0016363nuclear matrix
CCISSGO:0045121membrane raft

Gene expression in normal tissue: SORBS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SORBS1


DatabasePathway IDPathway Des.
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-445355Smooth Muscle Contraction
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP481Insulin Signaling
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
pidinsulin_pathwayInsulin Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SORBS1

​​​​