SORBS1
Summary: This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sorbin and SH3 domain containing 1 | MIM:605264 | Ensembl:ENSG00000095637 | HGNC:HGNC:14565 | PA37899 | 10q24.1 |
GO terms in SORBS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003779 | actin binding |
| MF | IC | GO:0005070 | SH3/SH2 adaptor activity |
| MF | ISS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IDA | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008092 | cytoskeletal protein binding |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | TAS | GO:0007160 | cell-matrix adhesion |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0043149 | stress fiber assembly |
| BP | ISS | GO:0045725 | positive regulation of glycogen biosynthetic process |
| BP | ISS | GO:0046326 | positive regulation of glucose import |
| BP | ISS | GO:0046889 | positive regulation of lipid biosynthetic process |
| BP | ISS | GO:0048041 | focal adhesion assembly |
| BP | ISS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | ISS | GO:2001275 | positive regulation of glucose import in response to insulin stimulus |
| CC | ISS | GO:0001725 | stress fiber |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005813 | centrosome |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005899 | insulin receptor complex |
| CC | ISS | GO:0005913 | cell-cell adherens junction |
| CC | TAS | GO:0005915 | zonula adherens |
| CC | ISS | GO:0005924 | cell-substrate adherens junction |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | ISS | GO:0045121 | membrane raft |
Gene expression in normal tissue: SORBS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SORBS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP481 | Insulin Signaling |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| pid | insulin_pathway | Insulin Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SORBS1
CLASSFICATION
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