SORBS1

Summary: This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesorbin and SH3 domain containing 1
OMIM IDMIM:605264
Ensembl IDEnsembl:ENSG00000095637
HGNC IDHGNC:HGNC:14565
PHARMGKB IDPA37899
Map Location10q24.1

GO terms in SORBS1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003779 actin binding
MF IC GO:0005070 SH3/SH2 adaptor activity
MF ISS GO:0005070 SH3/SH2 adaptor activity
MF IDA GO:0005158 insulin receptor binding
MF IPI GO:0005515 protein binding
MF TAS GO:0008092 cytoskeletal protein binding
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Gene expression in normal tissue: SORBS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SORBS1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-445355 Smooth Muscle Contraction
wikipathways WP185 Integrin-mediated Cell Adhesion
wikipathways WP3942 PPAR signaling pathway
wikipathways WP481 Insulin Signaling
kegg hsa03320 PPAR signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SORBS1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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