SLCO1B1
Summary: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier organic anion transporter family member 1B1 | MIM:604843 | Ensembl:ENSG00000134538 | HGNC:HGNC:10959 | PA134865839 | 12p12.1 |
GO terms in SLCO1B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| BP | TAS | GO:0015711 | organic anion transport |
| BP | IBA | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | IBA | GO:0043252 | sodium-independent organic anion transport |
| BP | TAS | GO:0043252 | sodium-independent organic anion transport |
| BP | IEA | GO:0055085 | transmembrane transport |
| BP | IEA | GO:0070327 | thyroid hormone transport |
| MF | IBA | GO:0015125 | bile acid transmembrane transporter activity |
| MF | TAS | GO:0015125 | bile acid transmembrane transporter activity |
| MF | IBA | GO:0015347 | sodium-independent organic anion transmembrane transporter activity |
| MF | TAS | GO:0015347 | sodium-independent organic anion transmembrane transporter activity |
| MF | TAS | GO:0015349 | thyroid hormone transmembrane transporter activity |
Gene expression in normal tissue: SLCO1B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLCO1B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5619102 | SLC transporter disorders |
| reactome | R-HSA-5619110 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5661182 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) |
| reactome | R-HSA-879518 | Transport of organic anions |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| smpdb | SMP00653 | Rosiglitazone Metabolism Pathway |
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP229 | Irinotecan Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011109 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011111 | Fluvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011112 | Rosuvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA146123006 | Codeine and Morphine Pathway, Pharmacokinetics |
| pharmgkb | PA153627759 | Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics |
| pharmgkb | PA154423659 | Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165816969 | Rosiglitazone Pharmacokinetic Pathway |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA166041114 | Ibuprofen Pathway, Pharmacokinetics |
| pharmgkb | PA2001 | Irinotecan Pathway, Pharmacokinetics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLCO1B1
CLASSFICATION
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