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SIX2

Summary: This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
SIX homeobox 2	MIM:604994	Ensembl:ENSG00000170577	HGNC:HGNC:10888	PA35788	2p21

Gene Categories:

TRANSCRIPTION FACTOR BINDING

GO terms in SIX2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000976	transcription regulatory region sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MF	NAS	GO:0003700	DNA-binding transcription factor activity
MF	IEA	GO:0008134	transcription factor binding
MF	IEA	GO:0044877	protein-containing complex binding
BP	IBA	GO:0001822	kidney development
BP	IMP	GO:0001822	kidney development
BP	ISS	GO:0001822	kidney development
BP	IEA	GO:0002062	chondrocyte differentiation
BP	ISS	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	IEA	GO:0006606	protein import into nucleus
BP	ISS	GO:0007501	mesodermal cell fate specification
BP	IDA	GO:0008283	cell proliferation
BP	TAS	GO:0009653	anatomical structure morphogenesis
BP	ISS	GO:0009948	anterior/posterior axis specification
BP	IDA	GO:0016477	cell migration
BP	IEA	GO:0030278	regulation of ossification
BP	IEA	GO:0032330	regulation of chondrocyte differentiation
BP	IEA	GO:0042474	middle ear morphogenesis
BP	IEA	GO:0045596	negative regulation of cell differentiation
BP	IBA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0048557	embryonic digestive tract morphogenesis
BP	IEA	GO:0048701	embryonic cranial skeleton morphogenesis
BP	IBA	GO:0048856	anatomical structure development
BP	ISS	GO:0072006	nephron development
BP	ISS	GO:0072028	nephron morphogenesis
BP	ISS	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis
BP	IEA	GO:0072137	condensed mesenchymal cell proliferation
BP	ISS	GO:0072161	mesenchymal cell differentiation involved in kidney development
BP	ISS	GO:0090189	regulation of branching involved in ureteric bud morphogenesis
BP	ISS	GO:0097168	mesenchymal stem cell proliferation
BP	ISS	GO:1902732	positive regulation of chondrocyte proliferation
CC	IBA	GO:0005634	nucleus
CC	IEA	GO:0005634	nucleus
CC	IBA	GO:0005667	transcription factor complex

Gene expression in normal tissue: SIX2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIX2

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIX2

SITE

DATATYPES

CLASSFICATION

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