CHL1
Summary: The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell adhesion molecule L1 like | MIM:607416 | Ensembl:ENSG00000134121 | HGNC:HGNC:1939 | PA26470 | 3p26.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CHL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002020 | protease binding |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0045177 | apical part of cell |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0031103 | axon regeneration |
| BP | IEA | GO:0035640 | exploration behavior |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0050890 | cognition |
Gene expression in normal tissue: CHL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447041 | CHL1 interactions |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD480 | KU0060648 | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD652 | UNC0638 | 1 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHL1
CLASSFICATION
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