SRSF10


Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

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Name
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Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in SRSF10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IBA GO:0003723 RNA binding
MF IDA GO:0003723 RNA binding
MF NAS GO:0003723 RNA binding
MF IPI GO:0005515 protein binding
MF NAS GO:0050733 RS domain binding
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Gene expression in normal tissue: SRSF10

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in SRSF10


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Database
Pathway ID
Pathway Des.
wikipathways WP2001 miR-targeted genes in adipocytes - TarBase
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2003 miR-targeted genes in leukocytes - TarBase
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
wikipathways WP2005 miR-targeted genes in muscle cell - TarBase
wikipathways WP411 mRNA Processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRSF10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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