SRSF10
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:605221 Ensembl IDEnsembl:ENSG00000188529 HGNC IDHGNC:HGNC:16713 PHARMGKB IDPA28427 Map Location1p36.11 |
GO terms in SRSF10
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | HDA | GO:0003723 | RNA binding |
MF | IBA | GO:0003723 | RNA binding |
MF | IDA | GO:0003723 | RNA binding |
MF | NAS | GO:0003723 | RNA binding |
MF | IPI | GO:0005515 | protein binding |
MF | NAS | GO:0050733 | RS domain binding |
Gene expression in normal tissue: SRSF10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRSF10
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2001 | miR-targeted genes in adipocytes - TarBase |
wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
wikipathways | WP411 | mRNA Processing |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SRSF10
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |