HSPH1

Summary: This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameheat shock protein family H (Hsp110) member 1
OMIM IDMIM:610703
Ensembl IDEnsembl:ENSG00000120694
HGNC IDHGNC:HGNC:16969
PHARMGKB IDPA134869917
Map Location13q12.3

GO terms in HSPH1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000774 adenyl-nucleotide exchange factor activity
MF TAS GO:0000774 adenyl-nucleotide exchange factor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0043014 alpha-tubulin binding
CC TAS GO:0005576 extracellular region
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Gene expression in normal tissue: HSPH1

Gene-model tissue-cancer distribution: Bubble Plot

STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophagogastric Adenocarcinoma (EGC) model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 2

Gene-drug pathway distribution

DNA replication1Bile secretion1undefined1

Pathways in HSPH1


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Database
Pathway ID
Pathway Des.
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
wikipathways WP3395 Cellular response to heat stress
reactome R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
reactome R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
reactome R-HSA-2262752 Cellular responses to stress
reactome R-HSA-3000484 Scavenging by Class F Receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD368 Oxaliplatin 1
iGMDRD21 Fluorouracil 2
iGMDRD160 Cis-Platin 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPH1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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