GADD45G
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604949 Ensembl IDEnsembl:ENSG00000130222 HGNC IDHGNC:HGNC:4097 PHARMGKB IDPA28512 Map Location9q22.2 | |||||
GO terms in GADD45G
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0000185 | activation of MAPKKK activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006950 | response to stress |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: GADD45G
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GADD45G
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GADD45G
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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