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PRDX3

Summary: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
peroxiredoxin 3	MIM:604769	Ensembl:ENSG00000165672	HGNC:HGNC:9354	PA33724	10q26.11

Gene Categories:

KINASE PROTEASE PROTEASE INHIBITOR

GO terms in PRDX3

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008022	protein C-terminus binding
MF	EXP	GO:0008379	thioredoxin peroxidase activity
MF	IDA	GO:0008379	thioredoxin peroxidase activity
MF	NAS	GO:0008785	alkyl hydroperoxide reductase activity
MF	IPI	GO:0019900	kinase binding
MF	IPI	GO:0019901	protein kinase binding
MF	IPI	GO:0042802	identical protein binding
MF	IMP	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	TAS	GO:0005759	mitochondrial matrix
CC	IDA	GO:0005769	early endosome
CC	IDA	GO:0005829	cytosol
CC	IPI	GO:0008385	IkappaB kinase complex
CC	IDA	GO:0032991	protein-containing complex
CC	IEA	GO:0043209	myelin sheath
BP	IEA	GO:0001893	maternal placenta development
BP	IEA	GO:0006915	apoptotic process
BP	IMP	GO:0006979	response to oxidative stress
BP	IMP	GO:0007005	mitochondrion organization
BP	IDA	GO:0008284	positive regulation of cell proliferation
BP	IDA	GO:0018171	peptidyl-cysteine oxidation
BP	ISS	GO:0030099	myeloid cell differentiation
BP	ISS	GO:0032496	response to lipopolysaccharide
BP	IDA	GO:0033673	negative regulation of kinase activity
BP	IDA	GO:0034599	cellular response to oxidative stress
BP	TAS	GO:0034599	cellular response to oxidative stress
BP	IMP	GO:0034614	cellular response to reactive oxygen species
BP	IDA	GO:0042542	response to hydrogen peroxide
BP	IDA	GO:0042744	hydrogen peroxide catabolic process
BP	IMP	GO:0042744	hydrogen peroxide catabolic process
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IEA	GO:0045454	cell redox homeostasis
BP	IDA	GO:0051092	positive regulation of NF-kappaB transcription factor activity
BP	IMP	GO:0051881	regulation of mitochondrial membrane potential
BP	IEA	GO:0098869	cellular oxidant detoxification

Gene expression in normal tissue: PRDX3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDX3

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-3299685	Detoxification of Reactive Oxygen Species
reactome	R-HSA-8953897	Cellular responses to external stimuli
wikipathways	WP15	Selenium Micronutrient Network
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDX3

SITE

DATATYPES

CLASSFICATION

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