MAPRE2
Summary: The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule associated protein RP/EB family member 2 | MIM:605789 | Ensembl:ENSG00000166974 | HGNC:HGNC:6891 | PA30635 | 18q12.1-q12.2 |
GO terms in MAPRE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0051010 | microtubule plus-end binding |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| BP | IBA | GO:0035372 | protein localization to microtubule |
| BP | IBA | GO:0051225 | spindle assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:1904825 | protein localization to microtubule plus-end |
| CC | HDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005815 | microtubule organizing center |
| CC | IBA | GO:0005874 | microtubule |
| CC | IBA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IBA | GO:0035371 | microtubule plus-end |
| CC | IEA | GO:0035371 | microtubule plus-end |
| CC | IBA | GO:0051233 | spindle midzone |
Gene expression in normal tissue: MAPRE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPRE2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPRE2
CLASSFICATION
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