STMN2

Summary: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namestathmin 2
OMIM IDMIM:600621
Ensembl IDEnsembl:ENSG00000104435
HGNC IDHGNC:HGNC:10577
PHARMGKB IDPA35540
Map Location8q21.13

GO terms in STMN2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0015631 tubulin binding
MF IPI GO:0048306 calcium-dependent protein binding
BP IBA GO:0007019 microtubule depolymerization
BP IDA GO:0007026 negative regulation of microtubule depolymerization
BP IDA GO:0010976 positive regulation of neuron projection development
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Gene expression in normal tissue: STMN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STMN2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STMN2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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