STMN2
Summary: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stathmin 2 | MIM:600621 | Ensembl:ENSG00000104435 | HGNC:HGNC:10577 | PA35540 | 8q21.13 |
GO terms in STMN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015631 | tubulin binding |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| BP | IBA | GO:0007019 | microtubule depolymerization |
| BP | IDA | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IDA | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0010977 | negative regulation of neuron projection development |
| BP | IDA | GO:0031115 | negative regulation of microtubule polymerization |
| BP | IDA | GO:0031117 | positive regulation of microtubule depolymerization |
| BP | IBA | GO:0031175 | neuron projection development |
| BP | IBA | GO:0051493 | regulation of cytoskeleton organization |
| BP | IDA | GO:1990090 | cellular response to nerve growth factor stimulus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005768 | endosome |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030426 | growth cone |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: STMN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STMN2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STMN2
CLASSFICATION
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