Summary: This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008].

TRIO and F-actin binding proteinMIM:609761Ensembl:ENSG00000100106HGNC:HGNC:17009PA14267069922q13.1

GO terms in TRIOBP

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007049cell cycle
BPIEAGO:0007605sensory perception of sound
BPNASGO:0030047actin modification
BPNASGO:0051016barbed-end actin filament capping
BPIEAGO:0051017actin filament bundle assembly
BPIEAGO:0051301cell division
BPIEAGO:0060088auditory receptor cell stereocilium organization
BPIDAGO:1900026positive regulation of substrate adhesion-dependent cell spreading
CCIEAGO:0005815microtubule organizing center
CCHDAGO:0005925focal adhesion
CCIDAGO:0015629actin cytoskeleton
CCNASGO:0015629actin cytoskeleton
CCIEAGO:0032437cuticular plate
CCIEAGO:0120043stereocilium shaft
CCIEAGO:0120044stereocilium base
MFNASGO:0017049GTP-Rho binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFNASGO:0045159myosin II binding
MFIDAGO:0051015actin filament binding

Gene expression in normal tissue: TRIOBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIOBP

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIOBP