TRIOBP
Summary: This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TRIO and F-actin binding protein | MIM:609761 | Ensembl:ENSG00000100106 | HGNC:HGNC:17009 | PA142670699 | 22q13.1 |
GO terms in TRIOBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | NAS | GO:0030047 | actin modification |
| BP | NAS | GO:0051016 | barbed-end actin filament capping |
| BP | IEA | GO:0051017 | actin filament bundle assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0060088 | auditory receptor cell stereocilium organization |
| BP | IDA | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | NAS | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0030496 | midbody |
| CC | IEA | GO:0032437 | cuticular plate |
| CC | IEA | GO:0120043 | stereocilium shaft |
| CC | IEA | GO:0120044 | stereocilium base |
| MF | NAS | GO:0017049 | GTP-Rho binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | NAS | GO:0045159 | myosin II binding |
| MF | IDA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: TRIOBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIOBP
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIOBP
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