CHGA
Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namechromogranin A OMIM IDMIM:118910 Ensembl IDEnsembl:ENSG00000100604 HGNC IDHGNC:HGNC:1929 PHARMGKB IDPA26461 Map Location14q32.12 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CHGA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002026 | regulation of the force of heart contraction |
| BP | IDA | GO:0002551 | mast cell chemotaxis |
| BP | ISS | GO:0006996 | organelle organization |
| BP | TAS | GO:0008217 | regulation of blood pressure |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | IEA | GO:0031640 | killing of cells of other organism |
Gene expression in normal tissue: CHGA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHGA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHGA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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