CHGA
Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromogranin A | MIM:118910 | Ensembl:ENSG00000100604 | HGNC:HGNC:1929 | PA26461 | 14q32.12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CHGA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002026 | regulation of the force of heart contraction |
| BP | IDA | GO:0002551 | mast cell chemotaxis |
| BP | ISS | GO:0006996 | organelle organization |
| BP | TAS | GO:0008217 | regulation of blood pressure |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | IEA | GO:0031640 | killing of cells of other organism |
| BP | IDA | GO:0032762 | mast cell cytokine production |
| BP | IBA | GO:0033604 | negative regulation of catecholamine secretion |
| BP | IDA | GO:0033604 | negative regulation of catecholamine secretion |
| BP | IBA | GO:0042742 | defense response to bacterium |
| BP | IDA | GO:0043303 | mast cell degranulation |
| BP | NAS | GO:0045087 | innate immune response |
| BP | IDA | GO:0045576 | mast cell activation |
| BP | IBA | GO:0046676 | negative regulation of insulin secretion |
| BP | IBA | GO:0046888 | negative regulation of hormone secretion |
| BP | IDA | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IDA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IEA | GO:0050832 | defense response to fungus |
| BP | ISS | GO:0060452 | positive regulation of cardiac muscle contraction |
| BP | IBA | GO:0086030 | adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation |
| BP | ISS | GO:0086030 | adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation |
| BP | ISS | GO:0097756 | negative regulation of blood vessel diameter |
| BP | ISS | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | ISS | GO:1901215 | negative regulation of neuron death |
| BP | ISS | GO:1901899 | positive regulation of relaxation of cardiac muscle |
| BP | ISS | GO:2000707 | positive regulation of dense core granule biogenesis |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005615 | extracellular space |
| CC | IBA | GO:0030141 | secretory granule |
| CC | ISS | GO:0030141 | secretory granule |
| CC | IEA | GO:0030658 | transport vesicle membrane |
| CC | IBA | GO:0042583 | chromaffin granule |
| CC | ISS | GO:0042583 | chromaffin granule |
| CC | IEA | GO:0042629 | mast cell granule |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: CHGA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHGA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHGA
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