CDC42EP1
Summary: CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
CDC42 effector protein 1 | MIM:606084 | Ensembl:ENSG00000128283 | HGNC:HGNC:17014 | PA38430 | 22q13.1 |
GO terms in CDC42EP1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0017049 | GTP-Rho binding |
MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
CC | IBA | GO:0005737 | cytoplasm |
CC | IBA | GO:0005856 | cytoskeleton |
CC | IEA | GO:0005856 | cytoskeleton |
CC | IBA | GO:0005886 | plasma membrane |
CC | HDA | GO:0005913 | cell-cell adherens junction |
CC | HDA | GO:0005925 | focal adhesion |
CC | IEA | GO:0012505 | endomembrane system |
BP | IBA | GO:0007266 | Rho protein signal transduction |
BP | IBA | GO:0008360 | regulation of cell shape |
BP | IDA | GO:0008360 | regulation of cell shape |
BP | IBA | GO:0030838 | positive regulation of actin filament polymerization |
BP | IBA | GO:0031274 | positive regulation of pseudopodium assembly |
BP | IDA | GO:0031274 | positive regulation of pseudopodium assembly |
BP | IEA | GO:0043547 | positive regulation of GTPase activity |
BP | IEA | GO:0098609 | cell-cell adhesion |
Gene expression in normal tissue: CDC42EP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC42EP1
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CDC42EP1