PTP4A3


Summary: This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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GO terms in PTP4A3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004725 protein tyrosine phosphatase activity
MF TAS GO:0004727 prenylated protein tyrosine phosphatase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity
BP IDA GO:0006355 regulation of transcription, DNA-templated
BP IEA GO:0007219 Notch signaling pathway
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Gene expression in normal tissue: PTP4A3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTP4A3


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Database
Pathway ID
Pathway Des.
pid prlsignalingeventspathway Signaling events mediated by PRL
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD792 Cetuximab 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTP4A3

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Cancer
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